Journal article
Psychological outcomes and surgical decisions after genetic testing in women newly diagnosed with breast cancer with and without a family history
B Meiser, VF Quinn, G Mitchell, K Tucker, KJ Watts, B Rahman, M Peate, C Saunders, E Geelhoed, M Gleeson, K Barlow-Stewart, M Field, M Harris, YC Antill, R Susman, MT Bowen, L Mills, J Kirk
European Journal of Human Genetics | NATURE PUBLISHING GROUP | Published : 2018
Abstract
In patients with early breast cancer, personal and tumour characteristics other than family history are increasingly used to prompt genetic testing to guide women's cancer management (treatment-focused genetic testing, 'TFGT'). Women without a known strong family history of breast and/or ovarian may be more vulnerable to psychological sequelae arising from TFGT. We compared the impact of TFGT in women with (FH+) and without (FH-) a strong family history on psychological adjustment and surgical decisions. Women aged <50 years with high-risk features were offered TFGT before definitive breast cancer surgery and completed self-report questionnaires at four time points over 12 months. All 128 wo..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank the patients who generously participated in this study. We also gratefully acknowledge the assistance of the staff who were involved at each site. Thank you also to Mariana Souza for research assistance. We also acknowledge the support and endorsement of this project by the Psycho-oncology Cooperative Research Group (PoCoG). This trial was funded by a Priority-Driven Collaborative Research Grant, which was jointly supported by Cancer Australia, Cancer Council Australia and the National Breast Cancer Foundation (ID 630405). Bettina Meiser was supported by a Career Development Fellowship Award Level 2 (ID 1003921) from the National Health and Medical Research Council (NHMRC) of Australia and an NHMRC Senior Research Fellowship Level B (ID 1078523). Michelle Peate is currently supported by a National Breast Cancer Foundation Early Career Fellowship (ECF-15-005).